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Rise in dehydroepiandrosterone and oestrogens during clomiphene administration in normal men.
- Source :
-
Acta endocrinologica [Acta Endocrinol (Copenh)] 1976 Sep; Vol. 83 (1), pp. 166-72. - Publication Year :
- 1976
-
Abstract
- Serum concentrations of LH, FSH and testosterone, and urinary excretion of individual 17-ketosteroids, oestrogenic substances and free cortisol was investigated in 12 normal men after a daily administration of 50 mg clomiphene citrate for 14 days. A significant increase in the serum concentrations of LH, FSH and testosterone was seen after 8 days with a further increase when measured a week later. The percentual increase in urinary excretion of oestrogens and dehydroepiandrosterone was of the same order as the increase in serum testosterone concentrations whereas the increase in androsterone and a aetiocholanolone was significantly lower. The excretion of free cortisol was unaltered. The study that measurements of oestrogens in the urine might be used as a parameter of the stimulatory effect of clomiphene on the hypothalamic - pituitary - gonadal axis in man. In addition, of the results support the hypothesis of an independent effect of clomiphene on adrenal steroidogenesis, not related to the production of glucocorticoids.
- Subjects :
- 17-Ketosteroids urine
Adult
Androsterone urine
Clomiphene administration & dosage
Etiocholanolone urine
Follicle Stimulating Hormone blood
Humans
Hydrocortisone urine
Luteinizing Hormone blood
Male
Stimulation, Chemical
Testosterone blood
Clomiphene pharmacology
Dehydroepiandrosterone urine
Estrogens urine
Subjects
Details
- Language :
- English
- ISSN :
- 0001-5598
- Volume :
- 83
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Acta endocrinologica
- Publication Type :
- Academic Journal
- Accession number :
- 134615
- Full Text :
- https://doi.org/10.1530/acta.0.0830166