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[An electron microscopic study of the behavioral characteristics of human lung tumor cells cultured on soft agar].

Authors :
Semiachkina SO
Klimashevskiĭ VF
Pozharisskiĭ KM
Source :
Tsitologiia [Tsitologiia] 1992; Vol. 34 (11-12), pp. 51-4.
Publication Year :
1992

Abstract

The ultrastructure of cells from seven human lung cancers and from the colonies formed by these cells in soft agar was investigated. Tumor cells developed to display the morphofunctional potentials of the initial tumors. Cultured cells of squamous-cell carcinomas contained numerous tonofilaments, those of adenocarcinomas developed microvilli on their apical surfaces and intracellular lumens. On the other hand, cells of squamous-cell carcinomas showed features specific of adenoma epithelium, i.e. well developed microvilli and intracellular lumens. Besides, cells of adenocarcinoma often contained large quantities of tonofilaments considered to be characteristic of epidermoid epithelium. The results obtained suggest a possibility of metaplastic transformation of the lung epithelium.

Details

Language :
Russian
ISSN :
0041-3771
Volume :
34
Issue :
11-12
Database :
MEDLINE
Journal :
Tsitologiia
Publication Type :
Academic Journal
Accession number :
1338818