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Effects of converting enzyme inhibitors and the calcium antagonist nifedipine alone and in combination on precontracted isolated rabbit aortic rings.
- Source :
-
Arzneimittel-Forschung [Arzneimittelforschung] 1992 Jun; Vol. 42 (6), pp. 795-7. - Publication Year :
- 1992
-
Abstract
- The calcium antagonist nifedipine markedly relaxed intact rabbit aortic rings precontracted with low level potassium chloride while converting enzyme (CE) inhibitors, ramiprilat, enalaprilat, and captopril were only marginally effective. Either CE inhibitor combined with nifedipine, however, significantly accentuated this relaxation. The CE inhibitors increased vascular cyclic GMP content while nifedipine was not active. Thus, inhibition of potassium chloride-induced calcium influx by nifedipine may unmask the vasorelaxant potential of CE inhibitors that in turn may result from local accumulation of endothelium-derived bradykinin.
- Subjects :
- Angiotensin-Converting Enzyme Inhibitors administration & dosage
Animals
Aorta, Thoracic drug effects
Cyclic GMP metabolism
Female
In Vitro Techniques
Male
Muscle Contraction drug effects
Muscle Relaxation drug effects
Nifedipine administration & dosage
Nitric Oxide pharmacology
Potassium Chloride pharmacology
Rabbits
Angiotensin-Converting Enzyme Inhibitors pharmacology
Muscle, Smooth, Vascular drug effects
Nifedipine pharmacology
Vasodilator Agents pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0004-4172
- Volume :
- 42
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Arzneimittel-Forschung
- Publication Type :
- Academic Journal
- Accession number :
- 1329777