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Comparison of carbon monoxide and nitrogen induced effects on synaptic transmission in the rat hippocampal slice.
- Source :
-
Neuroscience letters [Neurosci Lett] 1992 Apr 13; Vol. 138 (1), pp. 9-13. - Publication Year :
- 1992
-
Abstract
- A comparison has been made of the effects of carbon monoxide (CO) or nitrogen (N2) exposure on synaptic transmission in the hippocampal slice. CA1 field potentials, evoked by Schaffer collateral stimulation, were unaffected by superfusion of slices with artificial cerebral spinal fluid (ACSF) equilibrated with either 15% CO or 15% N2 for 120 min. However, superfusion with hypoxic ACSF equilibrated with either 85% CO or 85% N2 caused a rapid depression of synaptic transmission. Reperfusion with control ACSF following 30 min hypoxia led to recovery of evoked responses and a slight hyperexcitability. In the hippocampal slice, synaptic transmission, as assessed by input/output curves, was not different during or following hypoxia induced by exposure to CO or N2. In the short term, CO is not toxic.
- Subjects :
- Afferent Pathways physiology
Animals
Evoked Potentials drug effects
In Vitro Techniques
Male
Nerve Fibers drug effects
Nerve Fibers physiology
Rats
Rats, Wistar
Synapses drug effects
Carbon Monoxide pharmacology
Hippocampus physiology
Nitrogen pharmacology
Synapses physiology
Synaptic Transmission drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0304-3940
- Volume :
- 138
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Neuroscience letters
- Publication Type :
- Academic Journal
- Accession number :
- 1328960
- Full Text :
- https://doi.org/10.1016/0304-3940(92)90460-o