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UV light-induced reactivation of herpes simplex virus type 2 and prevention by acyclovir.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 1992 Sep; Vol. 166 (3), pp. 500-6. - Publication Year :
- 1992
-
Abstract
- UV B light is a potent stimulus for inducing reactivation of latent herpes simplex virus (HSV) infections. Patients were enrolled in a double-blind placebo-controlled crossover trial to determine whether acyclovir can prevent UV light-induced HSV-2 recurrences. Twenty-four patients with a history of recurrent infection of perigenital sites (e.g., buttock, thigh) were exposed one to four times with 4 minimum erythema doses of UV light. Patients were given acyclovir 200 mg orally five times daily or matched placebo beginning 1 day before each exposure and continuing for 5 days after exposure. There were 13 UV-induced recurrences among 36 placebo treatments and 3 after 38 acyclovir treatments (P = .004). The mean time to recurrence (+/- SE) was 4.8 +/- 0.3 days. HSV-2 lesions developed primarily at the site of UV exposure. The cutaneous distribution and timing of UV-induced recurrences was consistent with a neural localization (dorsal root ganglia) of latent viral infection. This UV light model permits direct examination of events leading to HSV-2 recurrences in humans and can be used to evaluate approaches to prevention.
- Subjects :
- Adolescent
Adult
Double-Blind Method
Female
Herpes Simplex microbiology
Humans
Male
Middle Aged
Simplexvirus radiation effects
Acyclovir therapeutic use
Herpes Simplex drug therapy
Simplexvirus growth & development
Ultraviolet Rays
Virus Activation drug effects
Virus Activation radiation effects
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1899
- Volume :
- 166
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 1323616
- Full Text :
- https://doi.org/10.1093/infdis/166.3.500