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Delineation of the phagocyte NADPH oxidase through studies of chronic granulomatous diseases of childhood.
- Source :
-
Current opinion in immunology [Curr Opin Immunol] 1992 Feb; Vol. 4 (1), pp. 53-6. - Publication Year :
- 1992
-
Abstract
- The phagocyte NADPH oxidase is a complex system consisting of membrane and cytosolic components that must assemble at the membrane for proper activation. Studies of patients with chronic granulomatous diseases of childhood have enabled the molecular characterization of these components, which has led to studies defining their interaction during NADPH complex assembly. Understanding NADPH oxidase assembly provides an opportunity to develop therapeutics for the regulation of this important reaction of inflammation.
- Subjects :
- Child
Cytochrome b Group genetics
Cytochrome b Group metabolism
Cytosol metabolism
Enzyme Induction
Granulomatous Disease, Chronic genetics
Granulomatous Disease, Chronic pathology
Humans
Membrane Proteins genetics
Membrane Proteins metabolism
Multienzyme Complexes genetics
NADH, NADPH Oxidoreductases genetics
NADPH Oxidases
Neutrophils enzymology
Protein Processing, Post-Translational
Respiratory Burst
Superoxides metabolism
Granulomatous Disease, Chronic enzymology
Multienzyme Complexes metabolism
NADH, NADPH Oxidoreductases metabolism
Phagocytes enzymology
Subjects
Details
- Language :
- English
- ISSN :
- 0952-7915
- Volume :
- 4
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Current opinion in immunology
- Publication Type :
- Academic Journal
- Accession number :
- 1317712
- Full Text :
- https://doi.org/10.1016/0952-7915(92)90124-w