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WS-7338, new endothelin receptor antagonists isolated from Streptomyces sp. No. 7338. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities.
- Source :
-
The Journal of antibiotics [J Antibiot (Tokyo)] 1992 Jan; Vol. 45 (1), pp. 74-82. - Publication Year :
- 1992
-
Abstract
- WS-7338 A, B, C and D, novel endothelin receptor antagonists, have been isolated from fermentation broth of Streptomyces sp. No. 7338. These antagonists were purified from the culture mycelium by extraction with acetone, followed by carbon column chromatography and HPLC. Among them, WS-7338 B showed good activity in an endothelin receptor binding assay with an IC50 of 2.7 x 10(-7) M.
- Subjects :
- Amino Acid Sequence
Animals
Aorta
Bacteria drug effects
Chromatography
Fermentation
Fungi drug effects
Humans
Hydrogen-Ion Concentration
Magnetic Resonance Spectroscopy
Microscopy, Electron, Scanning
Molecular Sequence Data
Peptides, Cyclic biosynthesis
Peptides, Cyclic isolation & purification
Peptides, Cyclic pharmacology
Receptors, Endothelin
Solubility
Streptomyces classification
Streptomyces ultrastructure
Swine
Endothelins metabolism
Endothelium, Vascular metabolism
Peptides, Cyclic chemistry
Receptors, Cell Surface antagonists & inhibitors
Streptomyces metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0021-8820
- Volume :
- 45
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The Journal of antibiotics
- Publication Type :
- Academic Journal
- Accession number :
- 1312521
- Full Text :
- https://doi.org/10.7164/antibiotics.45.74