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Synaptosomal membrane fluidity, lipid peroxidation and superoxide dismutase activity in the brain of amygdala-kindled rats.

Authors :
Itoh T
Akiyama K
Hiramatsu M
Otsuki S
Source :
The Japanese journal of psychiatry and neurology [Jpn J Psychiatry Neurol] 1992 Dec; Vol. 46 (4), pp. 957-66.
Publication Year :
1992

Abstract

Synaptosomal membrane fluidity, lipid peroxide (LPO) and cytosolic superoxide dismutase (SOD) activity were examined in various brain regions (amygdala, hippocampus, striatum and frontal cortex) of amygdala-kindled rats. At 24 h after the last seizure, a significant increase of membrane fluidity was observed in all the regions examined, whereas the LPO level was significantly decreased in the four regions with enhanced activity of cytosolic SOD. At 7 days after the last seizure, membrane fluidity was decreased only in the hippocampus. At 6 weeks after the last seizure, there were no changes in membrane fluidity between control and kindled rats. These results suggest that membrane fluidity and lipid peroxidation are modulated transiently by a kindled seizure, but not at a steady state of kindling with enduring seizure susceptibility.

Details

Language :
English
ISSN :
0912-2036
Volume :
46
Issue :
4
Database :
MEDLINE
Journal :
The Japanese journal of psychiatry and neurology
Publication Type :
Academic Journal
Accession number :
1304622
Full Text :
https://doi.org/10.1111/j.1440-1819.1992.tb02867.x