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Transport parameter estimation from lymph measurements and the Patlak equation.
- Source :
-
The American journal of physiology [Am J Physiol] 1992 Jan; Vol. 262 (1 Pt 2), pp. H293-8. - Publication Year :
- 1992
-
Abstract
- Two methods of estimating protein transport parameters for plasma-to-lymph transport data are presented. Both use IBM-compatible computers to obtain least-squares parameters for the solvent drag reflection coefficient and the permeability-surface area product using the Patlak equation. A matrix search approach is described, and the speed and convenience of this are compared with a commercially available gradient method. The results from both of these methods were different from those of a method reported by Reed, Townsley, and Taylor [Am. J. Physiol. 257 (Heart Circ. Physiol. 26): H1037-H1041, 1989]. It is shown that the Reed et al. method contains a systematic error. It is also shown that diffusion always plays an important role for transmembrane transport at the exit end of a membrane channel under all conditions of lymph flow rate and that the statement that diffusion becomes zero at high lymph flow rate depends on a mathematical definition of diffusion.
Details
- Language :
- English
- ISSN :
- 0002-9513
- Volume :
- 262
- Issue :
- 1 Pt 2
- Database :
- MEDLINE
- Journal :
- The American journal of physiology
- Publication Type :
- Academic Journal
- Accession number :
- 1301007
- Full Text :
- https://doi.org/10.1152/ajpheart.1992.262.1.H293