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Successful treatment of life-threatening generalized infantile myofibromatosis using low-dose chemotherapy.
- Source :
-
Journal of pediatric hematology/oncology [J Pediatr Hematol Oncol] 2003 Sep; Vol. 25 (9), pp. 750-4. - Publication Year :
- 2003
-
Abstract
- Infantile myofibromatosis is the most common fibrous tumor of infancy. The generalized form of the disease is associated with a high rate of early mortality, especially if visceral structures are involved. Various therapeutic strategies have been used in these patients, including high-dose chemotherapy, with the risk of therapy-related toxicity. The authors present two cases of generalized infantile myofibromatosis, with life-threatening visceral and nonvisceral involvement, in which the patients were cured with a combination of low-dose chemotherapy and intensive care. The authors propose a prospective international trial using a safe low-dose chemotherapy protocol to test the efficacy of this treatment strategy.
- Subjects :
- Combined Modality Therapy
Critical Care
Dactinomycin administration & dosage
Female
Humans
Infant, Newborn
Male
Methotrexate administration & dosage
Muscle Neoplasms congenital
Muscle Neoplasms drug therapy
Myofibromatosis congenital
Osteolysis
Prednisolone administration & dosage
Remission Induction
Respiration, Artificial
Skin Neoplasms congenital
Skin Neoplasms drug therapy
Soft Tissue Neoplasms congenital
Vinblastine administration & dosage
Vincristine administration & dosage
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Myofibromatosis drug therapy
Soft Tissue Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1077-4114
- Volume :
- 25
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Journal of pediatric hematology/oncology
- Publication Type :
- Academic Journal
- Accession number :
- 12972815
- Full Text :
- https://doi.org/10.1097/00043426-200309000-00016