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Neurological manifestations in HTLV-I-infected blood donors.
- Source :
-
Journal of the neurological sciences [J Neurol Sci] 2003 Oct 15; Vol. 214 (1-2), pp. 49-56. - Publication Year :
- 2003
-
Abstract
- The human T-cell lymphotropic virus type 1 (HTLV-I) causes a neurological disease known as HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in a minority of infected individuals. Although other neurological outcomes have been described their prevalence is presently unknown. To evaluate the frequency and characteristics of neurological involvement in a population of HTLV-I-infected blood donors we investigated 196 HTLV-I positive and 196 negative blood donors from a blood center of Rio de Janeiro, Brazil. Individuals with abnormalities at the neurological examination were examined by three neurologists, and when pertinent, additional neurological investigations were performed. Descriptive analysis, Student's t-test and chi2 test were employed for statistical analysis. Neurological abnormalities were found in 71 (36.2%) of the HTLV-I positive blood donors and in only 29 (14.8%) of the HTLV-I negative donors (OR = 2.54, 95% CI = 1.67-3.59, p = 0.000002). Cases of myelopathy, motor neuron disease and myopathy were only found in the HTLV-I positive group. In addition, peripheral neuropathy (PN) was significantly more frequent in the positive group (p = 0.015). In summary, our data suggest that HTLV-I-infected individuals exhibit a wide variety of neurological manifestations apart from the classical picture of HAM/TSP.
- Subjects :
- Adult
Brazil
Female
Human T-lymphotropic virus 1 isolation & purification
Humans
Male
Middle Aged
Motor Neuron Disease epidemiology
Motor Neuron Disease physiopathology
Muscular Diseases epidemiology
Muscular Diseases physiopathology
Nervous System pathology
Nervous System virology
Neurologic Examination
Paraparesis, Tropical Spastic blood
Paraparesis, Tropical Spastic epidemiology
Peripheral Nerves pathology
Peripheral Nerves physiopathology
Peripheral Nervous System Diseases epidemiology
Peripheral Nervous System Diseases physiopathology
Prevalence
Blood Donors
Nervous System physiopathology
Paraparesis, Tropical Spastic physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-510X
- Volume :
- 214
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Journal of the neurological sciences
- Publication Type :
- Academic Journal
- Accession number :
- 12972388
- Full Text :
- https://doi.org/10.1016/s0022-510x(03)00179-5