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Lithium treatment of acute mania in adolescents: a large open trial.
- Source :
-
Journal of the American Academy of Child and Adolescent Psychiatry [J Am Acad Child Adolesc Psychiatry] 2003 Sep; Vol. 42 (9), pp. 1038-45. - Publication Year :
- 2003
-
Abstract
- Objective: To examine initial response to treatment in a large sample of acutely manic bipolar I adolescents and to examine potential predictors of nonresponse, such as the presence of prominent depressive features, psychosis, or psychiatric comorbidity.<br />Method: Adolescents, 12 to 18 years of age, with an acute manic episode were treated with open lithium. Response was defined as a decline in Young Mania Rating Scale total score of >or=33% and a rating of "much improved" or "very much improved" on the Clinical Global Impressions Improvement item at week 4. Remission of mania was defined as a Young Mania Rating Scale score of <or=6. Axis I diagnoses were assessed using the Lifetime Schedule for Affective Disorders and Schizophrenia for Adolescents.<br />Results: Of 100 subjects, 63 met response criteria and 26 achieved remission of manic symptoms at the week 4 assessment. Prominent depressive features, age at first mood episode, severity of mania, and comorbidity with attention-deficit/hyperactivity disorder did not distinguish responders from nonresponders. When treated with adjunctive antipsychotic medication, subjects with psychotic features at baseline responded as well as subjects without psychosis.<br />Conclusions: In this largest systematic treatment trial of acutely manic adolescents to date, lithium appears effective for acute stabilization of symptoms. Controlled treatment studies in adolescents with acute mania are needed.
- Subjects :
- Acute Disease
Adolescent
Adolescent Psychiatry
Antimanic Agents administration & dosage
Attention Deficit Disorder with Hyperactivity psychology
Bipolar Disorder complications
Bipolar Disorder psychology
Child
Comorbidity
Depression
Female
Humans
Lithium Carbonate administration & dosage
Male
Treatment Outcome
Antimanic Agents pharmacology
Bipolar Disorder drug therapy
Lithium Carbonate pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0890-8567
- Volume :
- 42
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Journal of the American Academy of Child and Adolescent Psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 12960703
- Full Text :
- https://doi.org/10.1097/01.CHI.0000070247.24125.24