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Gene expression patterns in ovarian carcinomas.
- Source :
-
Molecular biology of the cell [Mol Biol Cell] 2003 Nov; Vol. 14 (11), pp. 4376-86. Date of Electronic Publication: 2003 Sep 05. - Publication Year :
- 2003
-
Abstract
- We used DNA microarrays to characterize the global gene expression patterns in surface epithelial cancers of the ovary. We identified groups of genes that distinguished the clear cell subtype from other ovarian carcinomas, grade I and II from grade III serous papillary carcinomas, and ovarian from breast carcinomas. Six clear cell carcinomas were distinguished from 36 other ovarian carcinomas (predominantly serous papillary) based on their gene expression patterns. The differences may yield insights into the worse prognosis and therapeutic resistance associated with clear cell carcinomas. A comparison of the gene expression patterns in the ovarian cancers to published data of gene expression in breast cancers revealed a large number of differentially expressed genes. We identified a group of 62 genes that correctly classified all 125 breast and ovarian cancer specimens. Among the best discriminators more highly expressed in the ovarian carcinomas were PAX8 (paired box gene 8), mesothelin, and ephrin-B1 (EFNB1). Although estrogen receptor was expressed in both the ovarian and breast cancers, genes that are coregulated with the estrogen receptor in breast cancers, including GATA-3, LIV-1, and X-box binding protein 1, did not show a similar pattern of coexpression in the ovarian cancers.
- Subjects :
- Adenocarcinoma metabolism
Adenocarcinoma, Clear Cell metabolism
Breast Neoplasms metabolism
Carcinoma, Papillary metabolism
Cation Transport Proteins genetics
Cation Transport Proteins metabolism
DNA-Binding Proteins genetics
DNA-Binding Proteins metabolism
Ephrin-B1 genetics
Ephrin-B1 metabolism
Female
GATA3 Transcription Factor
GPI-Linked Proteins
Humans
Immunohistochemistry
Membrane Glycoproteins genetics
Membrane Glycoproteins metabolism
Mesothelin
Neoplasm Proteins genetics
Neoplasm Proteins metabolism
Oligonucleotide Array Sequence Analysis
Ovarian Neoplasms metabolism
PAX8 Transcription Factor
Paired Box Transcription Factors
Receptors, Estrogen genetics
Receptors, Estrogen metabolism
Regulatory Factor X Transcription Factors
Trans-Activators genetics
Trans-Activators metabolism
Transcription Factors genetics
Transcription Factors metabolism
Tumor Cells, Cultured
Adenocarcinoma genetics
Adenocarcinoma, Clear Cell genetics
Breast Neoplasms genetics
Carcinoma, Papillary genetics
Nuclear Proteins
Ovarian Neoplasms genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1059-1524
- Volume :
- 14
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Molecular biology of the cell
- Publication Type :
- Academic Journal
- Accession number :
- 12960427
- Full Text :
- https://doi.org/10.1091/mbc.e03-05-0279