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Selective effect of oleamide, an endogenous sleep-inducing lipid amide, on pentylenetetrazole-induced seizures in mice.
- Source :
-
The Journal of pharmacy and pharmacology [J Pharm Pharmacol] 2003 Aug; Vol. 55 (8), pp. 1159-62. - Publication Year :
- 2003
-
Abstract
- The anti-seizure effect of oleamide, an endogenous sleep-inducing fatty acid amide, was studied in mice. Oleamide, in the dose range 43.7-700.0 mg kg(-1), significantly and dose-dependently inhibited the seizures induced by pentylenetetrazole. However, oleamide showed no inhibitory action on the seizures induced by picrotoxin, strychnine, caffeine or semicarbazide. These results provide the first evidence for the anti-seizure effect of oleamide, and suggest that this effect may be selective to the seizure model induced by pentylenetetrazole.
- Subjects :
- Animals
Diazepam pharmacokinetics
Dose-Response Relationship, Drug
Male
Mice
Oleic Acids pharmacokinetics
Seizures drug therapy
Sleep drug effects
Sleep physiology
Convulsants adverse effects
Diazepam administration & dosage
Oleic Acids administration & dosage
Pentylenetetrazole adverse effects
Seizures chemically induced
Seizures prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 0022-3573
- Volume :
- 55
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- The Journal of pharmacy and pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 12956907
- Full Text :
- https://doi.org/10.1211/0022357021431