Back to Search
Start Over
Acute motor axonal neuropathy rabbit model: immune attack on nerve root axons.
- Source :
-
Annals of neurology [Ann Neurol] 2003 Sep; Vol. 54 (3), pp. 383-8. - Publication Year :
- 2003
-
Abstract
- Macrophages in the periaxonal space and surrounding intact myelin sheath are the most prominent pathological feature of acute motor axonal neuropathy (AMAN). We describe this characteristic in nerve roots from paralyzed rabbits immunized with bovine brain ganglioside or GM1. IgG was deposited on nerve root axons. Distal nerve conduction was preserved, and late F wave components were absent during the acute phase. Initial lesions were located mainly on nerve root axons, as in human AMAN. This study thus provides supportive evidence that the rabbits constitute a model of AMAN.
- Subjects :
- Action Potentials physiology
Animals
Axons pathology
Axons ultrastructure
Electrophysiology
G(M1) Ganglioside immunology
Immunoglobulin G analysis
Immunohistochemistry
Macrophages immunology
Microscopy, Electron
Models, Animal
Motor Neurons immunology
Motor Neurons pathology
Neural Conduction physiology
Rabbits
Sciatic Nerve immunology
Sciatic Nerve pathology
Spinal Nerve Roots pathology
Spinal Nerve Roots ultrastructure
Wallerian Degeneration immunology
Wallerian Degeneration pathology
Axons immunology
Peripheral Nervous System Diseases immunology
Peripheral Nervous System Diseases pathology
Spinal Nerve Roots immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0364-5134
- Volume :
- 54
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Annals of neurology
- Publication Type :
- Academic Journal
- Accession number :
- 12953272
- Full Text :
- https://doi.org/10.1002/ana.33333