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[The temperature sensitivity of epidemic influenza A viruses as a marker of immunogenicity of reassortant vaccinal strains].
- Source :
-
Voprosy virusologii [Vopr Virusol] 2003 Jul-Aug; Vol. 48 (4), pp. 26-9. - Publication Year :
- 2003
-
Abstract
- The influence of ts-phenotype of epidemic viruses and of cold-adapted (CA) reassortant vaccines' strains, appropriately prepared, produced on the human immunogenicity was under investigation. A widespread variability of epidemic viruses' thermal sensitivity sign was established. It was shown that the CA reassortant vaccine strains, obtained through crossbreeding of attenuation donors and of thermally resistant epidemic viruses, are described by a higher immunogenicity. Therefore, the immunogenicity of live influenza vaccines (LIV) can be defined by the ts-phenotype of epidemic parent viruses, which must be sampled for the reassortant vaccine strains not only through searching for samples of antigenically actual viruses but also through search for non-ts-phenotype viruses.
- Subjects :
- Administration, Intranasal
Adolescent
Antibodies, Viral blood
Child
Humans
Influenza A virus genetics
Influenza Vaccines administration & dosage
Influenza Vaccines genetics
Influenza, Human blood
Phenotype
Reassortant Viruses genetics
Vaccination
Vaccines, Attenuated administration & dosage
Vaccines, Attenuated immunology
Cold Temperature
Influenza A virus immunology
Influenza Vaccines immunology
Influenza, Human immunology
Reassortant Viruses immunology
Subjects
Details
- Language :
- Russian
- ISSN :
- 0507-4088
- Volume :
- 48
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Voprosy virusologii
- Publication Type :
- Academic Journal
- Accession number :
- 12945203