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An echovirus type 33 winter outbreak in New Zealand.
- Source :
-
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2003 Sep 01; Vol. 37 (5), pp. 650-7. Date of Electronic Publication: 2003 Aug 07. - Publication Year :
- 2003
-
Abstract
- Echovirus type 33 (E33) is a relatively uncommon enterovirus. An E33 outbreak during the winter of 2000 in New Zealand led to 75 virologically-confirmed cases of E33 infection (2.6 cases per 100,000 individuals). Sixty-six (88%) of the 75 patients were aged <30 years, with the highest rates of infection recorded in Maori and Pacific ethnic groups. Overall, 47 (84%) of 56 patients whose cases were analyzed had either aseptic meningitis or encephalitis. Central nervous system involvement was more common after infancy (43 of 45 non-infant patients vs. 4 of 11 infants [relative risk, 2.6; 95% CI, 1.5-4.3]). Two infants died, including a neonate with fulminant hepatitis. Independent of symptom duration, neutrophil-predominant pleocytosis was detected in 17 (41%) of 41 cerebrospinal fluid specimens. Virus isolates could not be definitively typed by antibody neutralization testing but were identified as E33 by partial sequencing of the VP-1 capsid gene. The isolates were closely related to strains from Australia and Oman. Molecular typing, together with a serotype-specific E33 PCR, improved the speed and effectiveness of the outbreak investigation.
- Subjects :
- Adolescent
Adult
Child
Child, Preschool
Communicable Diseases drug therapy
Communicable Diseases epidemiology
Communicable Diseases mortality
Enterovirus B, Human drug effects
Enterovirus Infections drug therapy
Enterovirus Infections mortality
Female
Humans
Infant
Infant, Newborn
Male
Middle Aged
New Zealand epidemiology
Serotyping methods
Disease Outbreaks
Enterovirus B, Human isolation & purification
Enterovirus Infections epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1537-6591
- Volume :
- 37
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
- Publication Type :
- Academic Journal
- Accession number :
- 12942395
- Full Text :
- https://doi.org/10.1086/376915