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Reducing toxicity of cisplatin in cancer chemotherapy by extracorporeal removal of excess cisplatin.
- Source :
-
Journal of medicine [J Med] 2002; Vol. 33 (1-4), pp. 119-27. - Publication Year :
- 2002
-
Abstract
- Cisplatin and its derivatives are today among the most frequently used agents for treatment of malignancies, the dose, however, is limited by side effects. When an organ or extremity with tumor has a single, well defined artery, cisplatin can be delivered into the tumor, and cisplatin leaving the tumor through the venous drainage can be removed before it empties into the systemic circulation. We developed a hollow fiber device with an immobilized platinum chelator for extracorporeal removal of cisplatin, without the chelator entering the blood. When blood from melanoma patients, obtained during cisplatin infusion, was circulated through the device, 80% of the cisplatin was removed. In experiment using dogs cisplatin (100 mg/m2) was infused into the femoral vein, thus restricting cisplatin to the area to be treated. This method allows for applying high cisplatin doses locally, while reducing systemic side effects.
- Subjects :
- Animals
Antineoplastic Agents administration & dosage
Antineoplastic Agents blood
Chelating Agents
Chemotherapy, Cancer, Regional Perfusion instrumentation
Cisplatin administration & dosage
Cisplatin blood
Dogs
Extracorporeal Circulation instrumentation
Humans
In Vitro Techniques
Infusions, Intra-Arterial
Melanoma blood
Melanoma drug therapy
Neoplasms blood
Antineoplastic Agents adverse effects
Antineoplastic Agents isolation & purification
Cisplatin adverse effects
Cisplatin isolation & purification
Hemoperfusion instrumentation
Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0025-7850
- Volume :
- 33
- Issue :
- 1-4
- Database :
- MEDLINE
- Journal :
- Journal of medicine
- Publication Type :
- Academic Journal
- Accession number :
- 12939112