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Effect of mesitylene on ethanol metabolism in rat liver microsomes.
- Source :
-
Acta biochimica Polonica [Acta Biochim Pol] 1992; Vol. 39 (4), pp. 335-43. - Publication Year :
- 1992
-
Abstract
- Increased catalase activity was observed in the liver microsomal fraction of ethanol-treated rats (10% v/v aqueous ethanol solution per os for 5 weeks). In contrast, cytochrome P-450 concentration and specific activity of NADPH-cytochrome c reductase remained at the same level as in the liver of control rats (drinking water). The ratio of microsomal H2O2-generation to catalase activity was lower in the "ethanol" group than in the control one. This phenomenon seems to be related to the increased contribution of the "peroxidatic" reaction (increased rate of ethanol oxidation). Administration of mesitylene (1,3,5-trimethylbenzene) by gastric tube for 3 days (5 mmoles per kg daily) increased cytochrome P-450 concentration, specific activity of NADPH-cytochrome c reductase and ethanol metabolism.
- Subjects :
- Alcoholism metabolism
Animals
Catalase metabolism
Cytochrome P-450 Enzyme System metabolism
Ethanol pharmacology
Hydrogen Peroxide metabolism
Microsomes, Liver drug effects
NADPH-Ferrihemoprotein Reductase metabolism
Oxidation-Reduction
Rats
Benzene Derivatives pharmacology
Ethanol metabolism
Microsomes, Liver metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0001-527X
- Volume :
- 39
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Acta biochimica Polonica
- Publication Type :
- Academic Journal
- Accession number :
- 1293891