Serum TNF in patients with severe malaria treated by exchange transfusion.

Authors :: Loutan L
Plancherel C
Soulier-Lauper M
Pascual M
Subilia L
Chevrolet JC
Unger PF
Grau GE
Source :: Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ) [Trop Med Parasitol] 1992 Dec; Vol. 43 (4), pp. 285-6.
Publication Year :: 1992
Abstract: The authors report on three cases of severe P. falciparum malaria successfully treated by iv quinine and exchange transfusion. Serum concentrations of Tumor Necrosis Factor (TNF) were determined before and during treatment. After an initial decrease, serum levels of TNF remained markedly elevated during the first 48 hours despite exchange transfusion. Though exchange transfusion accelerates the elimination of parasites from the blood, it seems to have no immediate effects on reducing serum levels of cytokines such as TNF.

Subjects :: Adult
Chemotherapy, Adjuvant
Humans
Infusions, Intravenous
Malaria, Falciparum drug therapy
Malaria, Falciparum therapy
Male
Middle Aged
Quinine administration & dosage
Exchange Transfusion, Whole Blood
Malaria, Falciparum blood
Quinine therapeutic use
Tumor Necrosis Factor-alpha analysis

Language :: English
ISSN :: 0177-2392
Volume :: 43
Issue :: 4
Database :: MEDLINE
Journal :: Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ)
Publication Type :: Academic Journal
Accession number :: 1293736

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