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Surfactin/iturin A interactions may explain the synergistic effect of surfactin on the biological properties of iturin A.
- Source :
-
Biochimie [Biochimie] 1992 Dec; Vol. 74 (12), pp. 1047-51. - Publication Year :
- 1992
-
Abstract
- Iturin A and surfactin are two lipopeptides extracted from a same strain of Bacillus subtilis. Iturin A possesses antibiotic and antifungal activities and surfactin is a strong surfactant. The presence of surfactin, at a concentration at which, alone, it is inactive, increases to a very large extent the haemolysis percent induced by iturin A. This synergistic effect seems to be in relation with interactions between iturin A and surfactin. Iturin A adsorbs to and penetrates into surfactin monolayers. Iturin A and surfactin are miscible and interact specifically in mixed monolayers.
- Subjects :
- Adsorption
Amino Acid Sequence
Antibiotics, Antineoplastic chemistry
Antifungal Agents chemistry
Bacterial Proteins chemistry
Drug Interactions
Drug Synergism
Erythrocytes drug effects
Humans
Lipopeptides
Molecular Sequence Data
Peptides, Cyclic chemistry
Peptides, Cyclic pharmacology
Anti-Bacterial Agents
Antibiotics, Antineoplastic pharmacology
Antifungal Agents pharmacology
Bacterial Proteins pharmacology
Hemolysis drug effects
Peptides
Subjects
Details
- Language :
- English
- ISSN :
- 0300-9084
- Volume :
- 74
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Biochimie
- Publication Type :
- Academic Journal
- Accession number :
- 1292612
- Full Text :
- https://doi.org/10.1016/0300-9084(92)90002-v