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[The currently accepted pathophysiological model underlying surgical management of Parkinson disease].
- Source :
-
Neurologia i neurochirurgia polska [Neurol Neurochir Pol] 2003 Jan-Feb; Vol. 37 (1), pp. 203-13. - Publication Year :
- 2003
-
Abstract
- Among all the extrapiramidal movement disorders Parkinson's disease (PD) is the one most often submitted to neurosurgical treatment. Technical advances in neurosurgery, neuroimaging and neurophysiology, as well as shortcomings of chronic Levodopa medication (i.e. on/off fluctuations, violent dyskinesia and painful dystonia) have greatly contributed to the renewed interest in the surgical treatment of PD. The attainment of a better understanding of the basal ganglia function and of PD pathophysiology has also encouraged centers to treat Parkinson's disease in recent years. This article presents the current model of PD and the rationale for using GPi, thalamus and STN as target sites in stereotactic surgery.
- Subjects :
- Antiparkinson Agents therapeutic use
Basal Ganglia physiopathology
Basal Ganglia surgery
Basal Ganglia Diseases physiopathology
Basal Ganglia Diseases surgery
Electric Stimulation Therapy instrumentation
Humans
Levodopa therapeutic use
Parkinson Disease drug therapy
Radiosurgery instrumentation
Synaptic Transmission physiology
Ventral Thalamic Nuclei physiopathology
Ventral Thalamic Nuclei surgery
Neurosurgical Procedures methods
Parkinson Disease physiopathology
Parkinson Disease surgery
Thalamus surgery
Subjects
Details
- Language :
- Polish
- ISSN :
- 0028-3843
- Volume :
- 37
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Neurologia i neurochirurgia polska
- Publication Type :
- Academic Journal
- Accession number :
- 12910841