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Interactions between mitochondrial bioenergetics and cytoplasmic calcium in cultured cerebellar granule cells.
- Source :
-
Cell calcium [Cell Calcium] 2003 Oct-Nov; Vol. 34 (4-5), pp. 407-24. - Publication Year :
- 2003
-
Abstract
- The mitochondrion has moved to the center stage in the drama of the life and death of the neuron. The mitochondrial membrane potential controls the ability of the organelle to generate ATP, generate reactive oxygen species and sequester Ca(2+) entering the cell. Each of these processes interact, and their deconvolution is far from trivial. The cultured cerebellar granule cell provides a model in which knowledge gained from studies on isolated mitochondria can be applied to study the role played by the organelles in the maintenance of Ca(2+) homeostasis in the cell under resting, stimulated and pathophysiological conditions. In particular, mitochondria play a complex role in the response of the neuron to excitotoxic stimulation of NMDA and AMPA-kainate selective glutamate receptors. One goal of research in this area is to provide clues as to possible ways in which modulators of mitochondrial function may be used as neuroprotective agents, since mitochondrial Ca(2+) accumulation seems to play a key role in glutamate excitotoxicity.
- Subjects :
- Adenosine Triphosphate metabolism
Animals
Biological Transport physiology
Cell Death physiology
Cells, Cultured
Cerebellum cytology
Cerebellum metabolism
Cytoplasm metabolism
Glutamic Acid metabolism
Humans
Membrane Potentials physiology
Oligomycins pharmacology
Oxidative Phosphorylation drug effects
Pyruvic Acid metabolism
Reactive Oxygen Species metabolism
Receptors, Kainic Acid physiology
Receptors, N-Methyl-D-Aspartate physiology
Uncoupling Agents pharmacology
Calcium metabolism
Energy Metabolism physiology
Mitochondria physiology
Neurons physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0143-4160
- Volume :
- 34
- Issue :
- 4-5
- Database :
- MEDLINE
- Journal :
- Cell calcium
- Publication Type :
- Academic Journal
- Accession number :
- 12909085
- Full Text :
- https://doi.org/10.1016/s0143-4160(03)00144-1