Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE): Alzheimer's disease trial.

Authors :: Schneider LS
Ismail MS
Dagerman K
Davis S
Olin J
McManus D
Pfeiffer E
Ryan JM
Sultzer DL
Tariot PN
Source :: Schizophrenia bulletin [Schizophr Bull] 2003; Vol. 29 (1), pp. 57-72.
Publication Year :: 2003
Abstract: This article describes the development of the protocol for the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Alzheimer's disease trial, which was developed in collaboration with the National Institute of Mental Health to assess the effectiveness of atypical antipsychotics for psychosis and/or agitation occurring in outpatients with Alzheimer's disease. The article provides a detailed description of the methodology used in the trial as well as the clinical outcomes and effectiveness measures incorporated into it, discussing the most salient issues encountered in developing the design of the trial, as well as the unique features of the trial.

Subjects :: Aged
Algorithms
Alzheimer Disease diagnosis
Diagnostic and Statistical Manual of Mental Disorders
Double-Blind Method
Humans
Alzheimer Disease psychology
Antipsychotic Agents therapeutic use
Outcome and Process Assessment, Health Care
Psychomotor Agitation drug therapy
Psychomotor Agitation etiology
Psychotic Disorders drug therapy
Psychotic Disorders etiology
Randomized Controlled Trials as Topic standards

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