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[Neoadjuvant radiochemotherapy treatment in locally advanced rectal adenocarcinoma].
- Source :
-
Tumori [Tumori] 2003 Jul-Aug; Vol. 89 (4 Suppl), pp. 7-8. - Publication Year :
- 2003
-
Abstract
- A prospective phase II study was conducted to evacuate toxicity and results of preoperative radiochemotherapy in locoregionally advanced rectal cancer (LARC). A total of 33 patients entered the study and received 45 Gy to the pelvis plus a supplemental boost of 5.4-9 Gy concurrently with 5 FU c.i. at a dose of 225-275 mg/m2. Thirty patients were operated after 5-7 weeks (20 anterior resection and 10 abdominoperineal excision). In 14 patients (47%) a downstaging was observed, 5 patients experienced a complete clearance of the primary tumor. After a median of 14 months (range, 5-27), 23 patients, are alive and well. And 8 patients experienced a disease progression (4 local-regional and 4 distant). Our results provide further evidence of the utility and effectiveness of preoperative radiochemotherapy in LARC.
- Subjects :
- Adenocarcinoma drug therapy
Adenocarcinoma mortality
Adenocarcinoma radiotherapy
Adenocarcinoma surgery
Adult
Aged
Combined Modality Therapy
Disease Progression
Disease-Free Survival
Female
Humans
Male
Middle Aged
Photons therapeutic use
Prospective Studies
Rectal Neoplasms drug therapy
Rectal Neoplasms mortality
Rectal Neoplasms radiotherapy
Rectal Neoplasms surgery
Remission Induction
Treatment Outcome
Adenocarcinoma therapy
Antimetabolites, Antineoplastic therapeutic use
Chemotherapy, Adjuvant
Fluorouracil therapeutic use
Neoadjuvant Therapy
Radiotherapy, Adjuvant
Radiotherapy, High-Energy
Rectal Neoplasms therapy
Subjects
Details
- Language :
- Italian
- ISSN :
- 0300-8916
- Volume :
- 89
- Issue :
- 4 Suppl
- Database :
- MEDLINE
- Journal :
- Tumori
- Publication Type :
- Academic Journal
- Accession number :
- 12903531