Minichromosome maintenance 2 expression is correlated with mode of invasion and prognosis in oral squamous cell carcinomas.

Authors :: Kodani I
Osaki M
Shomori K
Araki K
Goto E
Ryoke K
Ito H
Source :: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology [J Oral Pathol Med] 2003 Sep; Vol. 32 (8), pp. 468-74.
Publication Year :: 2003
Abstract: Background: This study examined the immunohistochemical expression of cell-cycle related molecules as well as cell proliferation and pathologic findings in oral squamous cell carcinoma (SCC) in order to clarify their pathobiologic and prognostic significance.<br />Methods: A total of 46 oral SCC specimens were analyzed using Ki-67, minichromosome maintenance 2 (MCM2), p53, p27, p21, and TUNEL. Aspects including tumor differentiation, mode of carcinoma invasion, tumor metastasis, and patient prognosis were compared among the specimens.<br />Results: A significantly higher MCM2 labeling index (LI) was observed in the moderately differentiated SCCs when compared to the well-differentiated SCCs (P<0.05). The higher MCM2 LI was correlated with mode of invasion Grade 4 (infiltrative growth) and patient prognosis. In contrast, the LIs of Ki-67, TUNEL-signal, p53, p27, and p21 were not correlated with patient prognosis.<br />Conclusion: Higher MCM2 LI provides useful information for patient prognosis in oral SCCs.

Language :: English
ISSN :: 0904-2512
Volume :: 32
Issue :: 8
Database :: MEDLINE
Journal :: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Publication Type :: Academic Journal
Accession number :: 12901728
Full Text :: https://doi.org/10.1034/j.1600-0714.2003.00116.x

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