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Wilms tumor gene peptide-based immunotherapy for patients with overt leukemia from myelodysplastic syndrome (MDS) or MDS with myelofibrosis.
- Source :
-
International journal of hematology [Int J Hematol] 2003 Jul; Vol. 78 (1), pp. 56-61. - Publication Year :
- 2003
-
Abstract
- The Wilms tumor gene, WT1, is overexpressed not only in leukemias and myelodysplastic syndrome (MDS) but also in various types of solid tumors, including lung and breast cancer, and the WT1 protein is a tumor antigen for these malignancies. In clinical trials of WT1 peptide-based cancer immunotherapy, patients with overt leukemia from MDS or MDS with myelofibrosis were injected intradermally with 0.3 mg of an HLA-A*2402-restricted, 9-mer WT1 peptide emulsified with Montanide ISA51 adjuvant. Only a single dose of WT1 vaccination resulted in an increase in WT1-specific cytotoxic T-lymphocytes, which was followed by a rapid reduction in leukemic blast cells. Severe leukopenia and local erythema at the injection sites of WT1 peptide were observed as adverse effects. These results have provided us with the first clinical evidence suggesting that WT1 peptide-based immunotherapy is an attractive treatment for patients with leukemias or MDS.
- Subjects :
- Aged
Antigens, Neoplasm therapeutic use
Female
HLA-A Antigens administration & dosage
HLA-A Antigens therapeutic use
Humans
Leukemia etiology
Leukemia pathology
Male
Middle Aged
Peptide Fragments administration & dosage
Peptide Fragments immunology
Peptide Fragments therapeutic use
Primary Myelofibrosis pathology
Treatment Outcome
Vaccination
Antigens, Neoplasm administration & dosage
Immunotherapy methods
Leukemia therapy
Myelodysplastic Syndromes pathology
WT1 Proteins immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0925-5710
- Volume :
- 78
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- International journal of hematology
- Publication Type :
- Academic Journal
- Accession number :
- 12894852
- Full Text :
- https://doi.org/10.1007/BF02983241