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[Brain microdialysis of isolation-reared mice under freely-moving conditions].
- Source :
-
Nihon yakurigaku zasshi. Folia pharmacologica Japonica [Nihon Yakurigaku Zasshi] 2003 Aug; Vol. 122 (2), pp. 135-40. - Publication Year :
- 2003
-
Abstract
- Brain microdialysis has become a well established and a widely-used technique for in vivo measurement of extracellular levels of neurotransmitters. However, a single neurotransmitter in the perfusates has been measured in most studies. The present paper describes a simultaneous measurement of serotonin and dopamine release in the prefrontal cortex of mice. Using this technique, we examined the modulation by serotonin(1A) receptors of serotonin, dopamine, and noradrenaline release in the cortex of isolation-reared mice. The isolation-reared mouse is a useful model of complicated mood disorders including phenotypes of anxiety, depression, and aggression. The study shows that isolation rearing selectively decreases the sensitivity of serotonin(1A) receptors to increase dopamine release.
- Subjects :
- Animals
Disease Models, Animal
Dopamine analysis
Dopamine metabolism
Male
Mice
Mice, Inbred Strains
Neurotransmitter Agents metabolism
Norepinephrine analysis
Norepinephrine metabolism
Receptors, Serotonin metabolism
Receptors, Serotonin, 5-HT1
Serotonin analysis
Serotonin metabolism
Affective Disorders, Psychotic metabolism
Microdialysis methods
Neurotransmitter Agents analysis
Prefrontal Cortex metabolism
Social Isolation
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0015-5691
- Volume :
- 122
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Nihon yakurigaku zasshi. Folia pharmacologica Japonica
- Publication Type :
- Academic Journal
- Accession number :
- 12890899
- Full Text :
- https://doi.org/10.1254/fpj.122.135