Mastic gum has no effect on Helicobacter pylori load in vivo.

Authors :: Bebb JR
Bailey-Flitter N
Ala'Aldeen D
Atherton JC
Source :: The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2003 Sep; Vol. 52 (3), pp. 522-3. Date of Electronic Publication: 2003 Jul 29.
Publication Year :: 2003
Abstract: Objective: To determine whether mastic gum suppresses or eradicates Helicobacter pylori infection in humans.<br />Patients and Methods: Nine patients with H. pylori infection, and without gastroduodenal ulceration, were recruited from day-case endoscopy lists and treated with mastic 1 g four times daily for 14 days. [13C]Urea breath tests (UBTs) were carried out immediately before, on day 15 and 5 weeks after treatment with mastic.<br />Results: Mastic had no effect on H. pylori status in any of the eight completed patients; all remained H. pylori positive by UBT with no change in delta scores [pre-treatment mean +/- s.e.m. 19.1 +/- 3.7, day 15 (post-treatment) 18.7 +/- 3.8, P = 0.8, paired t-test].<br />Conclusion: Despite reported anti-H. pylori action in vitro, this preliminary study shows that mastic has no effect on H. pylori in humans.