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[HLA-DRB and -DQB allele contribution to narcolepsy susceptibility in Chinese patients with narcolepsy].

[HLA-DRB and -DQB allele contribution to narcolepsy susceptibility in Chinese patients with narcolepsy].

Authors :
Han F
Chen EZ
Wei HL
Dong XS
Li J
Li M
He QY
Ding DJ
Source :
Zhonghua yi xue za zhi [Zhonghua Yi Xue Za Zhi] 2003 Apr 25; Vol. 83 (8), pp. 644-6.
Publication Year :
2003

Abstract

Objectives: To study the association of narcolepsy with HLA class II alleles in Chinese narcoleptic patients.<br />Methods: 31 patients with narcolepsy underwent brain computed tomography (CT) scan and magnetic resonance imaging (MRI) testing. All patients received a MSLT test following a routine night's sleep, and serological HLA typing for HLA DR(2). 21 patients received PCR-SSP HLA DR and DQ typing.<br />Results: All patients had sleepiness and cataplexy. There was no evidence for other functional or structural diseases. Sleep paralysis was elicited in 45%; hypnagogic hallucinations, in 61%. Mean sleep latency on MSLT was 2.1 min +/- 1.3 min; sleep-onset rapid eye movement (SOREM) occurred during 2/5 naps in 30 of 31 patients. The average number and latency of SOREM episodes were 4.2 +/- 1.0 episodes and 4.0 min +/- 1.8 min, respectively. All patients but one were HLA DR(2) positive and 86% were HLADRB(1) * 1501-HLADQB(1)*0602 positive.<br />Conclusions: HLA DR(2) and HLADQw6 are markers for narcolepsy-cataplexy in Chinese.

Details

Language :
Chinese
ISSN :
0376-2491
Volume :
83
Issue :
8
Database :
MEDLINE
Journal :
Zhonghua yi xue za zhi
Publication Type :
Academic Journal
Accession number :
12887819