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Acute undifferentiated fever caused by infection with Japanese encephalitis virus.
- Source :
-
The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 2003 Jun; Vol. 68 (6), pp. 704-6. - Publication Year :
- 2003
-
Abstract
- To determine the proportion of acute undifferentiated fevers without neurologic deficits related to infection with Japanese encephalitis (JE) virus, flavivirus serology (dengue and JE) was performed in a cohort of 156 adults presenting to a hospital in Chiangrai, Thailand. Recent flavivirus infection was diagnosed for any individual with an IgM result > 40 units. A ratio of dengue virus IgM to JE virus IgM < 0.91 defined a JE virus infection. Diagnostic criteria for Japanese encephalitis were met in 22 individuals (14%), and were unequivocal in 8 patients. The admission findings in these eight subjects were similar to those described for other flavivirus infections. Thrombocytopenia was the most striking laboratory abnormality (median platelet count = 119,000/mm3, range = 44,000-236,000/mm3). Headache (75%), nausea (50%), myalgia (38%), rash (38%), and diarrhea (25%) were the most frequently encountered signs and symptoms. Infection with Japanese encephalitis virus is an underappreciated cause of acute undifferentiated fever in Asia.
- Subjects :
- Acute Disease
Adolescent
Adult
Dengue diagnosis
Dengue Virus immunology
Encephalitis, Japanese virology
Female
Humans
Immunoglobulin G blood
Immunoglobulin M blood
Male
Thailand
Antibodies, Viral blood
Encephalitis Virus, Japanese immunology
Encephalitis, Japanese diagnosis
Fever of Unknown Origin etiology
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9637
- Volume :
- 68
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- The American journal of tropical medicine and hygiene
- Publication Type :
- Academic Journal
- Accession number :
- 12887030