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[High dose ara-C therapy induced bradycardia in an acute myeloid leukemia patient with inv (16)(p13q22)].
- Source :
-
[Rinsho ketsueki] The Japanese journal of clinical hematology [Rinsho Ketsueki] 2003 Jun; Vol. 44 (6), pp. 404-6. - Publication Year :
- 2003
-
Abstract
- A 20-year-old Japanese woman was diagnosed as having acute myeloid leukemia with inv(16)(p13 q22). She achieved complete remission (CR) after treatment with a standard dose of cytarabine(ara-C) and idarubicin. She received high dose ara-C and etoposide for the 2nd consolidation chemotherapy. On the 5th fraction of high dose ara-C, her heart rate dropped to 52/minute and returned to 72/minute after the cessation of ara-C. After achieving informed consent, we gave her another course of high dose ara-C, which once again resulted in a decreased heart rate. This suggests that the administration of high dose ara-C could cause bradycardia.
- Subjects :
- Adult
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Chromosome Inversion
Chromosomes, Human, Pair 16 genetics
Cytarabine administration & dosage
Etoposide administration & dosage
Female
Humans
Idarubicin administration & dosage
Remission Induction
Bradycardia chemically induced
Cytarabine adverse effects
Leukemia, Myeloid, Acute drug therapy
Leukemia, Myeloid, Acute genetics
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0485-1439
- Volume :
- 44
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- [Rinsho ketsueki] The Japanese journal of clinical hematology
- Publication Type :
- Academic Journal
- Accession number :
- 12884821