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The cellular distribution and oxidation state of platinum(II) and platinum(IV) antitumour complexes in cancer cells.
- Source :
-
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry [J Biol Inorg Chem] 2003 Sep; Vol. 8 (7), pp. 726-32. Date of Electronic Publication: 2003 Jul 12. - Publication Year :
- 2003
-
Abstract
- The cellular distribution of platinum in A2780 ovarian cancer cells treated with cisplatin and platinum(IV) complexes with a range of reduction potentials has been examined using elemental analysis (synchrotron radiation-induced X-ray emission). The cellular distribution of platinum(IV) drugs after 24 h is similar to that of cisplatin, consistent with the majority of administered platinum(IV) drugs being reduced. Micro-X-ray absorption near-edge spectra of cells treated with cisplatin and platinum(IV) complexes confirmed the reduction of platinum(IV) to platinum(II). In cells treated, the most difficult to reduce complex, cis, trans, cis-[PtCl(2)(OH)(2)(NH(3))(2)], platinum(IV) was detected in the cells along with platinum(II). The observations are in accordance with the relative ease of reduction of the platinum(IV) complexes used and support the requirement of reduction for activation of platinum(IV) complexes.
- Subjects :
- Antineoplastic Agents chemistry
Biological Transport
Cell Line, Tumor
Cisplatin chemistry
Diagnostic Imaging
Female
Humans
Oxidation-Reduction
Platinum Compounds chemistry
Spectrometry, X-Ray Emission
Spectrum Analysis
X-Rays
Antineoplastic Agents pharmacokinetics
Cell Compartmentation
Cisplatin pharmacokinetics
Ovarian Neoplasms pathology
Platinum Compounds pharmacokinetics
Subjects
Details
- Language :
- English
- ISSN :
- 0949-8257
- Volume :
- 8
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 12884089
- Full Text :
- https://doi.org/10.1007/s00775-003-0471-6