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Cardiac troponin I release and cytokine response during experimental human endotoxaemia.
- Source :
-
Intensive care medicine [Intensive Care Med] 2003 Sep; Vol. 29 (9), pp. 1598-600. Date of Electronic Publication: 2003 Jul 17. - Publication Year :
- 2003
-
Abstract
- Objective: To study the relationship between cytokine levels and cardiac troponin I (cTnI).<br />Design: Prospective experimental study.<br />Setting: Intensive care unit of a university hospital.<br />Participants: Six healthy male volunteers. INTERVENTIONS. Endotoxin, 4 ng/kg, was given as a 1-min intravenous infusion.<br />Measurements and Results: Circulating cardiac troponin I levels and proinflammatory cytokines tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-8 (IL-8) were analysed at various time points during a 24-h period. TNF-alpha appeared in the circulation 30 min after injection (T=0.5 h), reaching peak levels (5,665+/-1,910 pg/ml) 2 h after infusion. At T=24 h TNF-alpha was still elevated in the circulation compared to T=0. None of the six volunteers had a cTnI value higher than 0.1 microg/l at T=0, 6 h or 24 h.<br />Conclusion: The presence of significant amounts of TNF-alpha, IL-6 and IL-8 in the systemic circulation does not lead to increased levels of cTnI in experimental human endotoxaemia.
- Subjects :
- Adult
Blood Pressure physiology
Body Temperature physiology
Creatine Kinase blood
Endotoxemia physiopathology
Escherichia coli Infections physiopathology
Heart Rate physiology
Humans
Male
Prospective Studies
Tumor Necrosis Factor-alpha metabolism
Cytokines blood
Endotoxemia blood
Escherichia coli Infections blood
Troponin I blood
Subjects
Details
- Language :
- English
- ISSN :
- 0342-4642
- Volume :
- 29
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Intensive care medicine
- Publication Type :
- Academic Journal
- Accession number :
- 12879237
- Full Text :
- https://doi.org/10.1007/s00134-003-1893-x