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In vitro activities of 25 quinolones and fluoroquinolones against liver and blood stage Plasmodium spp.
- Source :
-
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2003 Aug; Vol. 47 (8), pp. 2636-9. - Publication Year :
- 2003
-
Abstract
- The in vitro activities of 25 quinolones and fluoroquinolones against erythrocytic stages of Plasmodium falciparum and against liver stages of Plasmodium yoelii yoelii and P. falciparum were studied. All compounds were inhibitory for chloroquine-sensitive and chloroquine-resistant P. falciparum grown in red blood cells. This inhibitory effect increased with prolonged incubation and according to the logarithm of the drug concentration. Grepafloxacin, trovafloxacin, and ciprofloxacin were the most effective drugs, with 50% inhibitory concentrations of <10 micro g/ml against both strains. Only grepafloxacin, piromidic acid, and trovafloxacin had an inhibitory effect against hepatic stages of P. falciparum and P. yoelii yoelii; this effect combined reductions of the numbers and the sizes of schizonts in treated cultures. Thus, quinolones have a potential for treatment or prevention of malaria through their unique antiparasitic effect against erythrocytic and hepatic stages of Plasmodium.
- Subjects :
- 4-Quinolones
Animals
Cells, Cultured
Fluoroquinolones
Mice
Plasmodium growth & development
Plasmodium falciparum drug effects
Plasmodium falciparum genetics
Plasmodium yoelii drug effects
Plasmodium yoelii genetics
Anti-Infective Agents pharmacology
Erythrocytes parasitology
Liver parasitology
Plasmodium drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0066-4804
- Volume :
- 47
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Antimicrobial agents and chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 12878530
- Full Text :
- https://doi.org/10.1128/AAC.47.8.2636-2639.2003