Back to Search
Start Over
[Inflammatory rheumatism flare-up after surgical treatment of Cushing's disease: two cases].
- Source :
-
La Revue de medecine interne [Rev Med Interne] 1992 Jul-Aug; Vol. 13 (4), pp. 302-4. - Publication Year :
- 1992
-
Abstract
- The anti-inflammatory effect of natural glucocorticoids is often overlooked, as shown by these two cases of inflammatory rheumatism flare-up which occurred after surgical treatment of Cushing's syndrome. The disorder in the first case was exacerbation of a probable rheumatoid arthritis; in the second case an unlabelled inflammatory rheumatism appeared in a context of postoperative corticotropic deficiency. In both cases a purely substitutive hydrocortisone therapy resulted in dramatic regression of the articular symptoms. It is well known that rheumatismal manifestations may occur in patients with slow adrenal failure. The determinant factor seems to be a glucocorticoid deficiency, either isolated or associated with others, since cortisol exerts and anti-inflammatory activity. In patients with corticotropic deficiency following surgical treatment of Cushing's disease, the endogenous corticosteroid therapy of hypercortisolism is interrupted, allowing the aggravation or emergence of inflammatory rheumatism.
- Subjects :
- Adult
Arthritis, Rheumatoid diagnostic imaging
Arthritis, Rheumatoid drug therapy
Cushing Syndrome complications
Female
Humans
Hydrocortisone therapeutic use
Postoperative Complications
Radiography
Rheumatic Diseases diagnostic imaging
Rheumatic Diseases drug therapy
Arthritis, Rheumatoid etiology
Cushing Syndrome surgery
Rheumatic Diseases etiology
Subjects
Details
- Language :
- French
- ISSN :
- 0248-8663
- Volume :
- 13
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- La Revue de medecine interne
- Publication Type :
- Academic Journal
- Accession number :
- 1287774
- Full Text :
- https://doi.org/10.1016/s0248-8663(05)80307-8