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In vitro growth responses of bifidobacteria and enteropathogens to bovine and human lactoferrin.
- Source :
-
Digestive diseases and sciences [Dig Dis Sci] 2003 Jul; Vol. 48 (7), pp. 1324-32. - Publication Year :
- 2003
-
Abstract
- A series of in vitro experiments was performed to test the ability of bovine and human lactoferrin to influence the growth of the gram-positive probiotic bacteria, Bifidobacterium bifidum, Bifidobacterium infantis, and Lactobacillus acidophilus, as well as the gram-negative enteric bacteria, E. coli O157:H7 and Salmonella typhimurium. None of the lactoferrin preparations stimulated the growth of the tested strains. However, iron-free apo-lactoferrin (bovine and human) and 66% iron-saturated bovine lactoferrin dramatically slowed the growth of E. coli O157:H7 in single culture experiments, while 98% iron-saturated preparations had no effect. In coculture experiments of B. infantis and E. coli, the iron-limited preparations of lactoferrin also slowed the growth of the latter without inhibiting the bifidobacteria. These results suggest that lactoferrin in iron-limited forms may have the potential to be combined with probiotic bacteria in biotherapeutic products, which could help balance human gut microflora and limit the overgrowth of certain enteric microorganisms.
- Subjects :
- Animals
Bifidobacterium growth & development
Cattle
Escherichia coli growth & development
Humans
Iron Compounds pharmacology
Lactobacillus acidophilus growth & development
Salmonella typhimurium growth & development
Bifidobacterium drug effects
Escherichia coli drug effects
Lactobacillus acidophilus drug effects
Lactoferrin pharmacology
Salmonella typhimurium drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0163-2116
- Volume :
- 48
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Digestive diseases and sciences
- Publication Type :
- Academic Journal
- Accession number :
- 12870790
- Full Text :
- https://doi.org/10.1023/a:1024111310345