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Precore wild-type hepatitis B virus with G1896 in the resolution of persistent hepatitis B virus infection.
- Source :
-
Intervirology [Intervirology] 2003; Vol. 46 (3), pp. 157-63. - Publication Year :
- 2003
-
Abstract
- Objective: Factors influencing the resolution of persistent hepatitis B virus (HBV) infection were sought for.<br />Methods: The loss of hepatitis B surface antigen (HBsAg) from serum was correlated with mutations in HBV DNA for a hepatitis B e antigen (HBeAg)-minus phenotype in patients infected with HBV genotype C and positive for HBeAg at presentation.<br />Results: HBeAg turned negative in all the 22 patients in whom HBV infection resolved, but only in 11 of the 25 patients with severe liver diseases (100 vs. 44%, p = 0.0001). The precore wild type (G1896) persisted significantly more frequently in the 22 patients in whom HBV infection resolved than in the 11 patients who developed decompensated liver cirrhosis or hepatocellular carcinoma (15/22 or 68% vs. 1/11 or 9%, p = 0.005). The double mutation in the core promoter (T1762/A1764) was comparably frequent in the two groups of patients at presentation (14/22 or 64% vs. 7/11 or 64%) and >15 years thereafter (18/22 or 82% vs. 10/11 or 91%).<br />Conclusion: The precore wild type (G1896) would seem to facilitate the resolution of HBV infection, while the precore mutant (A1896) may induce severe liver diseases in patients with HBeAg-positive chronic hepatitis who have lost HBeAg from serum.<br /> (Copyright 2003 S. Karger AG, Basel)
- Subjects :
- Adult
DNA, Viral blood
DNA, Viral genetics
Disease Progression
Female
Hepatitis B Antibodies blood
Hepatitis B Surface Antigens blood
Hepatitis B e Antigens genetics
Hepatitis B e Antigens immunology
Hepatitis B, Chronic immunology
Hepatitis B, Chronic virology
Humans
Male
Middle Aged
Promoter Regions, Genetic
Hepatitis B Core Antigens genetics
Hepatitis B e Antigens blood
Hepatitis B virus immunology
Hepatitis B, Chronic physiopathology
Mutation
Protein Precursors genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0300-5526
- Volume :
- 46
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Intervirology
- Publication Type :
- Academic Journal
- Accession number :
- 12867753
- Full Text :
- https://doi.org/10.1159/000071456