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Adult lymphoblastic lymphoma: high incidence of central nervous system relapse in patients treated with the Stanford University protocol.
- Source :
-
Annals of oncology : official journal of the European Society for Medical Oncology [Ann Oncol] 1992 Dec; Vol. 3 (10), pp. 839-41. - Publication Year :
- 1992
-
Abstract
- Twelve adult patients with non-leukaemic lymphoblastic lymphoma were treated with combination chemotherapy and central nervous system prophylaxis according to the protocol developed at Stanford University. Despite strict adherence to the Stanford protocol, 4 of 12 patients relapsed in the CNS, all with meningeal disease. Only four of the 12 patients are in continuing complete remission 6 to 88 months from the completion of induction therapy. These results are inferior to those previously reported for this regimen, and fail to confirm the high rate of control of CNS disease.
- Subjects :
- Adolescent
Adult
Asparaginase therapeutic use
Cyclophosphamide therapeutic use
Doxorubicin therapeutic use
Humans
Methotrexate therapeutic use
Middle Aged
Prednisolone therapeutic use
Recurrence
Remission Induction
Treatment Outcome
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Brain Neoplasms secondary
Precursor Cell Lymphoblastic Leukemia-Lymphoma drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0923-7534
- Volume :
- 3
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Annals of oncology : official journal of the European Society for Medical Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 1286046
- Full Text :
- https://doi.org/10.1093/oxfordjournals.annonc.a058107