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Pediatric post-transplant diabetes: data from a large cohort of pediatric heart-transplant recipients.
- Source :
-
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [Am J Transplant] 2003 Aug; Vol. 3 (8), pp. 994-8. - Publication Year :
- 2003
-
Abstract
- A retrospective analysis of 381 pediatric heart-transplant recipients was performed to determine the frequency, characteristics, and risk factors for post-transplant diabetes. The rate of post-transplant diabetes was 1.8% with antithymocyte globulin, cyclosporine and azathioprine as primary immunosuppressive therapy. Time from transplant to diabetes was 0.25-13 years. Diabetes was characterized by reversibility, and lack of insulinopenia and autoimmunity. The post-transplant diabetes rate in tacrolimus-converted children (n = 45) was 8.8%. In tacrolimus-converted children, age at transplant, mean and maximum tacrolimus blood levels, and first-year rejection episodes were higher in the post-transplant diabetes group, which also consistently had DR-mismatched transplants and HLA DR3/DR4 haplotypes. Body mass index was not different between diabetic and control tacrolimus-converted children. In conclusion, pediatric post-transplant diabetes may be related to reversible insulin resistance. Tacrolimus levels, HLA DR mismatch, and older age at transplant may predispose to post-transplant diabetes.
- Subjects :
- Adolescent
Antilymphocyte Serum administration & dosage
Azathioprine administration & dosage
Child
Child, Preschool
Cohort Studies
Cyclosporine administration & dosage
Female
Humans
Immunosuppressive Agents administration & dosage
Infant
Male
Retrospective Studies
Diabetes Mellitus etiology
Heart Transplantation
Subjects
Details
- Language :
- English
- ISSN :
- 1600-6135
- Volume :
- 3
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
- Publication Type :
- Academic Journal
- Accession number :
- 12859535
- Full Text :
- https://doi.org/10.1034/j.1600-6143.2003.00186.x