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E4orf3 is necessary for enhanced S-phase replication of cell cycle-restricted subgroup C adenoviruses.

E4orf3 is necessary for enhanced S-phase replication of cell cycle-restricted subgroup C adenoviruses.

Authors :
Shepard RN
Ornelles DA
Source :
Journal of virology [J Virol] 2003 Aug; Vol. 77 (15), pp. 8593-5.
Publication Year :
2003

Abstract

E1B-55K-mutant or E4orf6-mutant adenoviruses replicate more effectively after infecting cells in S phase than after infecting cells in G(1). Enhanced S-phase replication of the E4orf6-mutant viruses requires the E4orf3 gene. This report demonstrates that the E4orf3 gene is also required for enhanced S-phase replication of the E1B-55K-mutant virus.

Details

Language :
English
ISSN :
0022-538X
Volume :
77
Issue :
15
Database :
MEDLINE
Journal :
Journal of virology
Publication Type :
Academic Journal
Accession number :
12857931
Full Text :
https://doi.org/10.1128/jvi.77.15.8593-8595.2003