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E4orf3 is necessary for enhanced S-phase replication of cell cycle-restricted subgroup C adenoviruses.
E4orf3 is necessary for enhanced S-phase replication of cell cycle-restricted subgroup C adenoviruses.
- Source :
-
Journal of virology [J Virol] 2003 Aug; Vol. 77 (15), pp. 8593-5. - Publication Year :
- 2003
-
Abstract
- E1B-55K-mutant or E4orf6-mutant adenoviruses replicate more effectively after infecting cells in S phase than after infecting cells in G(1). Enhanced S-phase replication of the E4orf6-mutant viruses requires the E4orf3 gene. This report demonstrates that the E4orf3 gene is also required for enhanced S-phase replication of the E1B-55K-mutant virus.
- Subjects :
- Adenovirus E1B Proteins genetics
Adenovirus E1B Proteins metabolism
Adenovirus E4 Proteins genetics
Adenoviruses, Human classification
Adenoviruses, Human genetics
Adenoviruses, Human pathogenicity
G1 Phase
HeLa Cells
Humans
Mutation
Adenovirus E4 Proteins metabolism
Adenoviruses, Human physiology
Cell Cycle
S Phase
Virus Replication
Subjects
Details
- Language :
- English
- ISSN :
- 0022-538X
- Volume :
- 77
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- Journal of virology
- Publication Type :
- Academic Journal
- Accession number :
- 12857931
- Full Text :
- https://doi.org/10.1128/jvi.77.15.8593-8595.2003