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NQO1 C609T polymorphism associated with esophageal cancer and gastric cardiac carcinoma in North China.
- Source :
-
World journal of gastroenterology [World J Gastroenterol] 2003 Jul; Vol. 9 (7), pp. 1390-3. - Publication Year :
- 2003
-
Abstract
- Aim: To investigate the association of the NQO1 (C609T) polymorphism with susceptibility to esophageal squamous cell carcinoma (ESCC) and gastric cardiac adenocarcinoma (GCA) in North China.<br />Methods: The NQO1 C609T genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis in 317 cancer patients (193 ESCC and 124 GCA) and 165 unrelated healthy controls.<br />Results: The NQO1 C609T C/C, C/T and T/T genotype frequency among healthy controls was 31.5 %, 52.1 % and 16.4 % respectively. The NQO1 T/T genotype frequency among ESCC patients (25.9 %) was significantly higher than that among healthy controls (chi(2)=4.79, P=0.028). The NQO1 T/T genotype significantly increased the risk for developing ESCC compared with the combination of C/C and C/T genotypes, with an age, sex and smoking status adjusted odds ratio (OR) of 1.78 (1.04-2.98). This increased susceptibility was pronounced in ESCC patients with family histories of upper gastrointestinal cancers (UGIC) (adjusted OR=2.20, 95 % CI=1.18-3.98). Similarly, the susceptibility of the NQO1 T/T genotype to GCA development was also observed among patients with family histories of UGIC, with an adjusted odds ratio of 2.55 (95 % CI=1.21-5.23), whereas no difference in NQO1 genotype distribution was shown among patients without family histories of UGIC.<br />Conclusion: Determination of the NQO1 C609T genotype may be used as a stratification marker to predicate the individuals at high risk for developing ESCC and GCA in North China.
- Subjects :
- Adenocarcinoma epidemiology
Adult
Aged
Carcinoma, Squamous Cell epidemiology
Case-Control Studies
China epidemiology
Esophageal Neoplasms epidemiology
Female
Genetic Predisposition to Disease epidemiology
Genotype
Humans
Male
Middle Aged
Stomach Neoplasms epidemiology
Adenocarcinoma genetics
Carcinoma, Squamous Cell genetics
Esophageal Neoplasms genetics
Polymorphism, Restriction Fragment Length
Stomach Neoplasms genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1007-9327
- Volume :
- 9
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- World journal of gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 12854127
- Full Text :
- https://doi.org/10.3748/wjg.v9.i7.1390