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[Nedaplatin and 5-fluorouracil combined with radiotherapy for advanced esophageal cancer].
- Source :
-
Gan to kagaku ryoho. Cancer & chemotherapy [Gan To Kagaku Ryoho] 2003 Jun; Vol. 30 (6), pp. 803-7. - Publication Year :
- 2003
-
Abstract
- We conducted a pilot study of nedaplatin + 5-fluorouracil (5-FU) combined with radiotherapy for 29 patients with primary advanced (stage IV) esophageal cancer. A complete remission (CR) was obtained in 4 (14%) and a partial response in 13 patients (response rate: 59%). The median survival time and one-year survival rate were 238 days and 34.5%, respectively. Of the 29 patients, 24 (83%) completed the treatment schedule and toxicity of stomatitis and the like was infrequent. In conclusion, these results suggest that the efficacy of nedaplatin + 5-FU combined with radiotherapy might not differ from that of cisplatin + 5-FU combined with radiotherapy. Clearly, the usefulness of this combined therapy needs to be assessed in multicenter phase III trials.
- Subjects :
- Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols adverse effects
Carcinoma, Squamous Cell mortality
Combined Modality Therapy
Drug Administration Schedule
Esophageal Neoplasms mortality
Female
Fluorouracil administration & dosage
Humans
Leukopenia chemically induced
Male
Middle Aged
Organoplatinum Compounds administration & dosage
Pilot Projects
Radiotherapy Dosage
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Carcinoma, Squamous Cell drug therapy
Carcinoma, Squamous Cell radiotherapy
Esophageal Neoplasms drug therapy
Esophageal Neoplasms radiotherapy
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0385-0684
- Volume :
- 30
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Gan to kagaku ryoho. Cancer & chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 12852347