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Replication of damaged DNA.
- Source :
-
Cell cycle (Georgetown, Tex.) [Cell Cycle] 2003 Jul-Aug; Vol. 2 (4), pp. 300-2. - Publication Year :
- 2003
-
Abstract
- DNA damage is generated continually inside cells. In order to be able to replicate past damaged bases (translesion synthesis), the cell employs a series of specialised DNA polymerases, which singly or in combination, are able to bypass many different types of damage. The polymerases have similar structural domains to classical polymerases, but they have a more open structure to allow altered bases to fit into their active sites. Although not required for replication of undamaged DNA, some at least of these polymerases are located in replication factories. Emerging evidence suggests that the polymerase switch from replicative to translesion polymerases might be mediated by post-translational modifications.
- Subjects :
- Animals
DNA-Directed DNA Polymerase genetics
DNA-Directed DNA Polymerase metabolism
Mice
Models, Molecular
Proliferating Cell Nuclear Antigen genetics
Proliferating Cell Nuclear Antigen metabolism
Protein Structure, Tertiary genetics
Protein Structure, Tertiary physiology
RNA-Binding Protein FUS genetics
Xeroderma Pigmentosum genetics
Xeroderma Pigmentosum metabolism
DNA Damage physiology
DNA Repair physiology
DNA Replication physiology
RNA-Binding Protein FUS metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1538-4101
- Volume :
- 2
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Cell cycle (Georgetown, Tex.)
- Publication Type :
- Academic Journal
- Accession number :
- 12851478