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Characteristics of GABAergic neurons in the superficial superior colliculus in mice.
- Source :
-
Neuroscience letters [Neurosci Lett] 2003 Jul 31; Vol. 346 (1-2), pp. 81-4. - Publication Year :
- 2003
-
Abstract
- We investigated characteristics of identified GABAergic neurons in slices of the superficial superior colliculus (sSC) using transgenic mice in which green fluorescent protein (GFP) is specifically expressed in GABAergic neurons. Whole-cell patch clamp recordings and intracellular staining with biocytin revealed electrophysiological and morphological properties of GFP-positive neurons. GFP-positive neurons had a tangentially elongated wide dendritic field. In response to depolarizing current pulses, most of the GFP-positive neurons showed either of two firing properties; 55% (n=36/65) generated successive spikes with a constant firing frequency and 22% (n=14/65) showed transient burst firing at a threshold level for spike generation. These results elucidate a functional heterogeneity of GABAergic neurons, and provide fundamental information to understand the function of the GABAergic system in the sSC.
- Subjects :
- Action Potentials physiology
Animals
Green Fluorescent Proteins
Luminescent Proteins biosynthesis
Luminescent Proteins genetics
Mice
Mice, Inbred C57BL
Mice, Inbred ICR
Mice, Transgenic
Neurons chemistry
Superior Colliculi chemistry
gamma-Aminobutyric Acid analysis
Neurons physiology
Superior Colliculi physiology
gamma-Aminobutyric Acid physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0304-3940
- Volume :
- 346
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Neuroscience letters
- Publication Type :
- Academic Journal
- Accession number :
- 12850553
- Full Text :
- https://doi.org/10.1016/s0304-3940(03)00570-6