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Early changes of oxalate and calcium urine excretion in those with calcium oxalate stone formation after extracorporeal shock wave lithotripsy.
- Source :
-
Urology [Urology] 2003 Jul; Vol. 62 (1), pp. 17-21. - Publication Year :
- 2003
-
Abstract
- Objectives: To determine the extent of transient changes of tubular function in idiopathic calcium-oxalate (CaOx) stone-bearing patients after extracorporeal shock wave lithotripsy (ESWL), calcium and oxalate excretion were measured before and after ESWL.<br />Methods: In 22 patients with renal CaOx stones, the plasma values and urine excretion of creatinine, calcium, oxalate, magnesium, and citrate were measured before and on days 1 and 2 after ESWL under conditions of a standardized diet. Overnight urine collection for an 8-hour period was used to measure the urine excretion, and the values were extrapolated to a 24-hour period. For calculation of the urine ion activity, the AP(CaOx) index EQ(s) and the CaOx risk index were used.<br />Results: After ESWL, hyperoxaluria was noted in 10 patients compared with 2 before ESWL. Hypercalciuria was seen in 11 patients after ESWL compared with 3 before. Combined hyperoxaluria and hypercalciuria was found in 7 patients after ESWL compared with 1 before. Both the oxalate/creatinine and calcium/creatinine ratios were significantly increased after ESWL. The AP(CaOx) index EQ(s) and the CaOx risk index were significantly increased after ESWL in patients with increased post-ESWL calcium and/or oxalate excretion.<br />Conclusions: Increased calcium and/or oxalate excretion can be seen in patients with CaOx stones early after ESWL. This increased excretion of lithogenic substances represents an increased risk of fragment apposition after ESWL for the group with a significantly increased AP(CaOx) index EQ(s) and CaOx risk index. Therefore, prophylactic measures in patients at risk early after ESWL might be warranted to prevent possible recurrent stone formation.
- Subjects :
- Adult
Aged
Calcium blood
Calcium Oxalate analysis
Citrates blood
Citrates urine
Creatinine blood
Creatinine urine
Female
Humans
Kidney Calculi chemistry
Kidney Calculi therapy
Kidney Tubules metabolism
Magnesium blood
Magnesium urine
Male
Middle Aged
Oxalates blood
Prospective Studies
Recurrence
Risk
Calcium urine
Kidney Calculi metabolism
Lithotripsy
Oxalates urine
Subjects
Details
- Language :
- English
- ISSN :
- 1527-9995
- Volume :
- 62
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Urology
- Publication Type :
- Academic Journal
- Accession number :
- 12837412
- Full Text :
- https://doi.org/10.1016/s0090-4295(03)00122-5