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Synthesis and antiviral evaluation of alpha-D-2',3'-didehydro-2',3'-dideoxy-3'-C-hydroxymethyl nucleosides.
- Source :
-
Nucleic acids research. Supplement (2001) [Nucleic Acids Res Suppl] 2001 (1), pp. 79-80. - Publication Year :
- 2001
-
Abstract
- A series of hydroxymethyl branched analogues of antiviral apio d4Ns was synthesized from D-arabinose. The SN2' ring opening reaction of 2,2'-anhydro-alpha-D-pyrimidinenucleoside (10) was mainly investigated. The reaction selectively gave SN2' adducts, which were deprotected to furnish the desired alpha-D-2',3'-didehydro-2',3'-dideoxy-3'-C-hydroxymethyl nucleosides (2).
Details
- Language :
- English
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nucleic acids research. Supplement (2001)
- Publication Type :
- Academic Journal
- Accession number :
- 12836273
- Full Text :
- https://doi.org/10.1093/nass/1.1.79