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Cytokines and immune activation in systolic heart failure: the role of Type D personality.
- Source :
-
Brain, behavior, and immunity [Brain Behav Immun] 2003 Aug; Vol. 17 (4), pp. 304-9. - Publication Year :
- 2003
-
Abstract
- The proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) and its soluble receptors 1 (sTNFR1) and 2 (sTNFR2) are predictors of mortality in chronic heart failure (CHF) but the determinants of these increased levels of disease-promoting cytokines are largely unknown. Type D personality refers to the combination of the tendency to experience negative emotions (negative affectivity) and the tendency to inhibit the expression of emotions in social interaction (social inhibition). Type D is an independent predictor of cardiac events in coronary patients who are at risk for CHF. The present study examined the effect of Type D personality on TNF-alpha, sTNFR1, and sTNFR2 in 42 men with CHF (meanage=57.9+/-10.5 years). There was a significant multivariate effect of Type D on TNF-alpha measures (p=.006); i.e., circulating levels of TNF-alpha (4.8+/-0.9 versus 2.5+/-0.2 pg/ml, p=.003), sTNFR1 (1814+/-314 versus 1134+/-78 pg/ml, p=.014), and sTNFR2 (2465+/-243 versus 1874+/-118 pg/ml, p=.019) were significantly higher in Type D patients as compared to non-Type D patients. The effect size (ES) of Type D personality ranged from rather large (sTNFR1, ES=0.77; sTNFR2, ES= 0.73) to large (TNF-alpha, ES=0.90). After controlling for ischemic etiology and severity of heart failure, Type D personality emerged as an independent predictor of increased circulating levels of both TNF-alpha (OR=9.5, 95% CI 2.1-43.8, p=.004) and TNF-alpha receptors (OR= 6.1, 95% CI 1.4-25.8, p=.014). These findings are consistent with the prognostic power of Type D personality regarding long-term morbidity and mortality in patients with established coronary heart disease. This study suggests that individual differences in personality contribute to the psychoneuroimmunological aspects of heart failure.
- Subjects :
- Affect
Aged
Chronic Disease
Cross-Sectional Studies
Humans
Inhibition, Psychological
Logistic Models
Male
Middle Aged
Multivariate Analysis
Odds Ratio
Personality Development
Heart Failure blood
Heart Failure immunology
Heart Failure psychology
Receptors, Tumor Necrosis Factor blood
Tumor Necrosis Factor-alpha analysis
Subjects
Details
- Language :
- English
- ISSN :
- 0889-1591
- Volume :
- 17
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Brain, behavior, and immunity
- Publication Type :
- Academic Journal
- Accession number :
- 12831833
- Full Text :
- https://doi.org/10.1016/s0889-1591(03)00060-6