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Receptor induction and targeted drug delivery: a new antileukaemia strategy.
- Source :
-
Expert opinion on biological therapy [Expert Opin Biol Ther] 2003 Jul; Vol. 3 (4), pp. 563-74. - Publication Year :
- 2003
-
Abstract
- Strategic modalities of drug delivery have the potential to greatly improve the therapeutic efficacy of available drugs in acute myelogenous leukaemia (AML). Folate receptor (FR) type beta is selectively expressed on the surface of approximately 70% of AMLs. Increased FR-beta expression in these cells can be induced by all-trans retinoic acid (ATRA) and other retinoid compounds in the absence of terminal differentiation or cell growth inhibition. An apparent post-transcriptional modification prevents FR-beta in normal haematopoietic cells from binding folate, in contrast to AML cells. FR-beta may, therefore, be used as a target for the selective delivery of chemotherapeutic drugs to AML cells; this treatment modality appears to be particularly efficacious when administered in conjunction with retinoid-induction of FR-beta. FR-targeted liposomal drug delivery can also bypass the P-glycoprotein (P-gp)-mediated drug efflux pump commonly associated with multiple drug resistance in AML. The rationale and merits of this novel experimental treatment for AML and the current status of this research are provided.
- Subjects :
- Animals
Anthracyclines administration & dosage
Anthracyclines therapeutic use
Antineoplastic Agents administration & dosage
Bone Marrow Transplantation methods
Carrier Proteins genetics
Doxorubicin administration & dosage
Doxorubicin therapeutic use
Drug Delivery Systems
Folate Receptors, GPI-Anchored
Humans
Mice
Mice, Inbred NOD
Mice, SCID
Receptors, Cell Surface genetics
Transcription, Genetic
Antineoplastic Agents therapeutic use
Carrier Proteins drug effects
Leukemia, Myeloid, Acute drug therapy
Receptors, Cell Surface drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2598
- Volume :
- 3
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Expert opinion on biological therapy
- Publication Type :
- Academic Journal
- Accession number :
- 12831362
- Full Text :
- https://doi.org/10.1517/14712598.3.4.563