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Relative binding activity of new antigestagens with progesterone receptors in human hyperplastic endometrium.
- Source :
-
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2002 Nov; Vol. 134 (5), pp. 445-7. - Publication Year :
- 2002
-
Abstract
- We determined the content and binding capacity of progesterone receptors in the endometrium of patients with adenomatous and fibroid polyps, adenocystic hyperplasia, and atypical hyperplasia before and after gestagen therapy. Hyperplasia of the endometrium was accompanied by changes in affinity of cytosolic progesterone receptors for antigestagens, which provides the possibility of individual correction of hormone therapy.
- Subjects :
- 17 alpha-Hydroxyprogesterone Caproate
Adult
Endometrial Hyperplasia drug therapy
Endometrial Hyperplasia pathology
Estrogen Receptor Modulators therapeutic use
Female
Humans
Hydroxyprogesterones therapeutic use
In Vitro Techniques
Kinetics
Middle Aged
Receptors, Progesterone drug effects
Endometrial Hyperplasia metabolism
Estrogen Receptor Modulators metabolism
Receptors, Progesterone metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0007-4888
- Volume :
- 134
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Bulletin of experimental biology and medicine
- Publication Type :
- Academic Journal
- Accession number :
- 12802447
- Full Text :
- https://doi.org/10.1023/a:1022682028745